Nolvadex (Tamoxifen Citrate)

Name: Tamoxifen citrate
Other common names and terms: Nolvadex, Nolva, SERM
Active Life: 6-7 days
Drug Class: Oral Selective Estrogen Receptor Modulator (SERM)
Common doses: Dependant on situation of use
Blood pressure: Unlikely
Acne: Possible
Water retention: No
Nolvadex (Tamoxifen Citrate) structure Nolvadex (Tamoxifen Citrate) Structure

Tamoxifen citrate is a drug that has beneficial anti-oestrogenic properties, which competitively binds to oestrogen receptors which therefore blocks oestrogen from exerting effect. Tamoxifen citrate is an effective treatment for breast cancer, as many cancers of the breast are responsive to oestrogen, and therefore tamoxifen citrates ability to block oestrogen from exerting its action is very welcome and effective. Nolvadex is the brand name of tamoxifen citrate, thus it is commonly referred to as nolvadex, or nolva for short.

The aromatase enzyme is capable of converting many anabolic androgenic steroids into the female hormone, oestrogen. Whilst some levels of oestrogen can actually be beneficial, excessive levels can bring about unwanted side effects to the user, such as water retention, possible increased fat storage, and gynecomastia.
Water retention can bring about a much less defined look to the user, as subcutaneous fluids increase. It can also bring about sudden increases in bodyweight to the user.
Gynecomastia is the formation of breast tissue, with sore and/or puffy nipples being early signs of its development. Use of an anti-oestrogen such as tamoxifen should be began as soon as possible to reduce the oestrogen exerting its effects which could worsen the condition. An anti-aromatase would be even more effective. If left untreated gynecomastia can develop to the point in which it is unsightly and can only be reversed via surgery.

With tamoxifen citrates ability to block oestrogen at the hypothalamus and pituitary, thus ceasing negative feedback inhibition, we have a drug that can successfully increase FSH (follicle stimulating hormone) and LH (luteinizing hormone) in the male body. This is very beneficial to the bodybuilder who has used suppressive anabolic androgenic steroids, as LH can stimulate the Leydig's cells in the testes, thus bringing about a positive effect on natural serum testosterone levels. This effect is very welcome after a steroid cycle in the aid to restore ones natural testosterone production.

Tamoxifen citrate is a common choice as a post cycle therapy (PCT) drug for many, which is usually effective in its testosterone producing effects. Some may opt to include the use of HCG during a cycle to avoid testicular atrophy, a hormone which mimics the actions of LH. This is usually used when the testes are in a prolonged inactive state due to heavy and prolonged suppressive cycle use. We have to remember that HCG will not only increase the production of testosterone in the testes, but also increase the rate of aromatising too. Combine this with the fact that tamoxifen citrate only blocks oestrogen effects, if we cease use of the tamoxifen citrate during HCG treatment we could be left with high oestrogen levels which could quickly bring on pronounced related side effects to the user. It is therefore wise to only cease use of tamoxifen citrate a few weeks after you cease use of HCG, hopefully allowing oestrogen levels to stabilise. Also of note is the fact HCG will not aid with restoring ones natural testosterone production post cycle, as previously believed by many. Due to the high aromatising that HCG causes, the increased oestrogen will inhabit the HPTA thus actully worsening the recovery.

The use of tamoxifen citrate as an anti-oestrogen is usually only advised if necessary. Oestrogen is infact beneficial in some regards, but when within a tolerable level. If side effects become noticed the use of tamoxifen citrate may control the situation. Many find taking 60mg on the first day, 40mg for a week, then 20mg until PCT begins, proves fruitful.
A great protocol for PCT use of tamoxifen citrate is to take 100mg on day one, 60mg for the next 10 days, then 40mg for a week, ending with 20mg for the last week.

While the use of tamoxifen citrate may be beneficial in the blocking on estrogenic effects, a stronger option may be needed, and for this we would look to opt for an anti-aromatase. Whilst an oestrogen agonist/antagonist such as tamoxifen citrate only blocks oestrogens effects, an anti-aromatase will work by slowing or halting the production of oestrogen in the first place. This may be of a more beneficial option for those using heavier cycles, or those prone to related side effects, as this methods is a lot more effective. The combination of both type of drugs may be fruitful by ceasing estrogenic effects via both mechanisms.

Important information

Articles about performance enhancing drugs are for informational purposes only and are not intended to encourage or promote the use of such substances. These substances should only ever be used under the advice and supervision of a qualified and licensed physician.

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